CIP Systems (Clean In Place)

CIP systems allow for automatic, reproducible, and verifiable cleaning of equipment and process circuits without requiring disassembly. They are designed to ensure the highest standards of hygiene and product safety, reducing manual intervention and ensuring stability in critical cleaning parameters.

CIP Systems (Clean In Place)

CIP systems allow for automatic, reproducible, and verifiable cleaning of equipment and process circuits without requiring disassembly. They are designed to ensure the highest standards of hygiene and product safety, reducing manual intervention and ensuring stability in critical cleaning parameters.

They are custom configured based on the type of installation, product, and regulatory requirements, facilitating qualification and validation processes in GMP environments.

Technology and design

Custom design and manufacturing with 3D model and P&ID validation
CIP or CIP/DIP configuration as required for drying
Fixed or mobile version according to plant layout
1 to 5 line cleaning in series or in parallel
Installation lengths up to 100 m
Line diameters between ½” and 4”
Optional deposit between 50 and 2000 L
Centrifugal or multistage pump according to application
Pump Protection via Level Detector
Automatic dosing of up to 2 chemicals
Flow, pressure, temperature, and conductivity control
Final conductivity and TOC control according to configuration
Time, flow rate, or volume control in drying phases
Instrumentation: pressure, temperature, level and 0.22 µm filter

Productive versatility

CIP of reactors

Designed for the comprehensive cleaning of reactors used in mixing, emulsifying, or dissolving liquid and semi-solid products. It enables automatic cleaning of the internal volume, lids, bottoms, agitators, and accessories using washing heads adapted to the equipment's geometry, ensuring homogeneous residue removal and facilitating GMP validation.

Hose cleaning

Aimed at the internal cleaning of process hoses without disassembly, even in long sections or flexible configurations. Flow control and turbulent flow generation allow for effective residue removal, reducing the risk of cross-contamination in multi-product facilities.

CIP for process lines

Enables automatic cleaning of pipes, valves, pumps and exchangers in manufacturing, filling or recirculation lines. The system guarantees complete circuit coverage, monitoring of critical parameters and cycle repeatability in simple or complex networks.

Fixed CIP System Configuration

Permanently installed on-site, directly connected to process equipment and networks. It is designed for facilities with high cleaning frequency and allows for full integration with automation systems and dedicated utilities, ensuring maximum stability and traceability.

Mobile CIP System Configuration

Mounted on a skid for easy movement to service different equipment within the plant. Maintains the same automatic process controls, providing operational flexibility when a permanent installation is not required.

Solutions and benefits

Automatic cleaning without equipment disassembly

They allow cleaning equipment and entire lines without manual intervention or disassembly.

Cleanliness cycle repeatability

Automatic control ensures that each cycle always runs under the same conditions.

Reduction of cross-contamination risk

Controlled cleaning between batches prevents product carryover in facilities multi-product.

Complete control of critical cleaning parameters

They allow monitoring flow rate, temperature, conductivity, and time throughout the entire cycle.

Adaptation of the system to the existing installation

They are dimensioned according to line length, number of equipment, and product characteristics.

Ease of validation in GMP environments

Parameter logging allows for the documentation and validation of cleaning cycles.

Applications

Pharmaceutical sector

Pharmaceutical formulation reactor cleaning
Product transfer line cleaning
Cleaning of bulk product deposits“
Hydroalcoholic circuit cleaning
Cleaning of mixing and processing equipment
Manufacturing auxiliary systems cleaning

Biotechnology sector

Fermentation bioreactor cleaning
Cleaning of culture medium lines
Cleaning of buffer solution circuits
Cleaning of auxiliary biological systems
Solution preparation equipment cleaning
Biotechnology Facility Cleaning

Cosmetics industry

Cleaning of cream and emulsion reactors
Cosmetic formulation line cleaning
Cosmetic systems cleaning
Cleaning lotion and gel deposits
Cleaning of cosmetic processing equipment
Product Transfer System Cleaning

Veterinary sector

Veterinary formulation reactor cleaning
Animal solution line cleaning
Cleaning of veterinary suspension deposits
Antiseptic product equipment cleaning
Veterinary Mixing System Cleaning
Animal hygiene facility cleaning