CIP / SIP Systems

CIP/SIP systems combine automated cleaning (CIP) and sterilization by clean steam (SIP) into a single solution, allowing for complete sanitization cycles without disassembling equipment or process lines.

They are designed for environments where, in addition to eliminating product residues, it is necessary to ensure sterile conditions before the start of manufacturing, facilitating comprehensive process validation in accordance with GMP requirements.

CIP / SIP Systems

CIP/SIP systems combine automated cleaning (CIP) and sterilization by clean steam (SIP) into a single solution, allowing for complete sanitization cycles without disassembling equipment or process lines.

They are designed for environments where, in addition to eliminating product residues, it is necessary to ensure sterile conditions before the start of manufacturing, facilitating comprehensive process validation in accordance with GMP requirements.

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Technology and design

Custom design and manufacturing with 3D model and P&ID validation
CIP/SIP/DIP configuration as required for drying
Cleaning and sterilization of 1 to 5 lines in series or parallel
Installation lengths up to 100 m
Line diameters between ½” and 4”
Optional deposit between 50 and 2000 L
Sterilizable centrifugal pump with open impeller
Pump Protection via Level Detector
Automatic dosing of up to 2 chemicals
CIP Control: flow, pressure, temperature, and conductivity
SIP Control: pressure, temperature, condensates, and time
F0 value control according to process
Clean steam required for SIP (minimum 2 barg)
Utilities CIP: water, filtered air 0.22 µm (WFI optional)

Applications

CIP/SIP of reactors

Allows for complete cleaning and sterilization runs in manufacturing reactors without manual intervention. The system ensures residue removal and subsequent validatable sterilization of the internal volume, agitators, and accessories before the next batch.

Hose CIP/SIP

Applicable to flexible circuits used in sterile processes, ensuring internal cleaning followed by clean steam sterilization. Reduces the risk of cross-contamination in multi-product facilities.

CIP/SIP for process lines

Designed for piping, valves, pumps, and exchangers in critical lines where both cleanliness and sterility are required. Automated control of all parameters allows for full-cycle repeatability and logging for validation.

Fixed CIP/SIP System Configuration

Permanent installation integrated into the plant, connected to purified water and clean steam networks. Allows for complete programmed cleaning and sterilization cycles with maximum operational stability and traceability.

Mobile CIP/SIP System Configuration

Permanent installation integrated into the plant, connected to purified water and clean steam networks. Allows for complete programmed cleaning and sterilization cycles with maximum operational stability and traceability.

Solutions and benefits

Cleaning and sterilization in a single system

They allow complete sanitization sequences to be run without changing facilities.

Rapid transition between production batches

The combination of CIP and SIP reduces turnaround times between production cycles.

Comprehensive control of cleaning and sterilization parameters

They automatically manage critical variables for both processes.

Full equipment preparation before manufacturing

The system ensures that the installation is clean and sterile before product contact.

Repeatability of sanitation cycles

Automation ensures that each cycle runs under controlled conditions.

Regulatory Compliance in Sterile Processes

They facilitate the validation of cleaning and sterilization in GMP environments.

Applications

Pharmaceutical sector

Cleaning and sterilization of pharmaceutical reactors
Sanitization of sterile product lines
Cleaning and sterilization of transfer circuits
Aseptic preparation before filling
Sanitization of formulation equipment
Cleaning and sterility control in process

Biotechnology sector

Cleaning and sterilization of bioreactors
Sanitization of culture media lines
Cleaning and sterilization of buffer solutions
Sterile preparation of biological systems
Sanitization of auxiliary equipment
Cleaning validation in biotechnological processes

Cosmetics industry

Cleaning and sterilization of cosmetic reactors
Sanitization of formulation lines
Hygienic preparation of equipment
Cleaning and sterilization of transfer systems
Sanitization of cosmetic circuits
Hygienic control in cosmetic production

Veterinary sector

Cleaning and sterilization of veterinary reactors
Sanitization of animal solution lines
Sterile preparation of veterinary equipment
Cleaning and sterilization of transfer systems
Sanitization of antiseptic equipment
Cleaning control in veterinary production
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